Colm Ryan
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Colm leads the UCD Cancer Data Lab where his group develop computational approaches to understand how mutations in cancer alter molecular interaction networks and to identify ways to target these alterations therapeutically. Colm is an Assistant Professor in the UCD School of Computer Science, a Senior Fellow in the Conway Institute of Biomolecular and Biomedical Research, and an Irish Research Council Laureate. Colm is also Deputy Head of Node for ELIXIR Ireland and an Investigator at Systems Biology Ireland. He has a degree in Computer Science from Trinity College Dublin and worked as a software developer for IBM before completing a PhD in computational biology at University College Dublin.
Relevant Publications
- Ryan, C.J., Devakumar, L.P.S., Pettitt, S.J., Lord, C.J. ‘Complex synthetic lethality in cancer Nature Genetics’ (2023)
- De Kegel, B., Ryan, C.J. ‘Paralog dispensability shapes homozygous deletion patterns in tumor genomes’ Molecular Systems Biology (2023)
- Tudose, C., Bond, J., Ryan, C.J. “Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity” NAR Cancer (2023)
- Upadhya, S.R., Ryan, C.J. ‘Experimental reproducibility limits the correlation between mRNA and protein abundances in tumor proteomic profiles’ Cell Reports Methods (2022)
- De Kegel, B., Quinn, N., Thompson, N.A., Adams, D.J., Ryan, C.J. ‘Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines’ Cell Systems (2021)
- Lord, C.J., Quinn, N., Ryan, C.J. ‘Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions’ eLife (2020)
- De Kegel, B., Ryan, C.J. ‘Paralog buffering contributes to the variable essentiality of genes in cancer cell lines’ PLoS Genetics (2019)
- Brough, R., Gulati, A., Haider, S., Kumar, R., Campbell, J., Knudsen, E., Pettitt, S.J., Ryan, C.J., Lord, C.J. ‘Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer’ Oncogene (2018)
- Ryan, C.J., Kennedy, S., Bajrami, I., Matallanas, D., Lord, C.J. ‘A compendium of co-regulated protein complexes in breast cancer reveals collateral loss events’ Cell Systems (2017)
- Bridgett, S., Campbell, J., Lord, C.J., Ryan, C.J. ‘CancerGD: a resource for identifying and interpreting genetic dependencies in cancer’ Cell Systems (2017)