Sumana Sharma
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I am a Sir Henry Wellcome Postdoctoral Fellow at The MRC Weatherall Institute of Molecular Medicine in Oxford. I am interested in studying how cells respond to extracellular cues using systems-level approaches. This interest started during in my PhD at the Wellcome Sanger Institute, where I developed a genetic-screening method to identify cellular pathways required for cell surface recognition. During my post-doc at EMBL-EBI, I utilised multi-omics and CRISPR datasets to define core- and context-specific dependencies of a cell. Currently, I am studying the mechanism of inhibitory receptor (e.g PD1) signalling in T cells using genetic screening approaches. I am also interested in defining the immune dependencies of cancer cells.
Relevant Publications
- Sharma S*#, Whitehead T*, Kotowski M, Ng EQZ, Clarke J, Leitner J, Chen Y-L, Santos AM, Steinberger P, Davis SJ#. A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells (2023). Life Science Alliance.
- Sharma S*#, Dincer C*, Weidemueller P, Wright GJ, Petsalaki E# (2020). CEN-tools: An integrative platform to identify the contexts of essential genes. Molecular Systems Biology.
- Sharma S, Petsalaki E (2019). Large-scale datasets uncovering cell signalling networks in cancer: context matters. Current Opinion in Genetics and Development.
- Voegtle T, Sharma S, Nagy Z, Mori J, Semeniak D, Geer MJ, Smith CW, Lane J, Pollack S, Lassila R, Jouppila A, Barr AJ, Ogg DJ, Howard TD, McMiken HJ, Warwicker J, Geh C, Rowlinson R, Abbott M, Schulze H, Wright GJ, Mazharian A, Fuetterer K, Rajesh S, Douglas MR, Senis YA (2019). Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. eLife.
- Sharma S, Bartholdson SJ, Couch ACM, Yusa K, Wright GJ (2018). Genome-scale identification of cellular pathways required for cell surface recognition. Genome Research
- Sharma S#, Petsalaki E (2018). Application of CRISPR-Cas9 based genome-wide screening approaches to study cellular signalling mechanisms. International Journal of Molecular Sciences, Special issue: Genome Editing